Endocrine Abstracts

Background: Central diabetes insipidus (DI) has now been described in a handful of case reports as a symptom of Covid-19 infection - associated with acute respiratory distress syndrome (ARDS)1 - and as a possible late onset sequela secondary to Covid-19 infection. It has also once been reported following immunization with mRNA Covid-19 vaccination. Our Trust serves a population of 612,000 and we have recently observed two cases of central DI, one post Covid-19 infection and on...

Introduction: 85% of cases of primary hyperparathyroidism are caused by a parathyroid adenoma. These are usually small in size, in the range of 70 mg to 1 g. Those weighing more than 2 g are classified as ‘giant adenomas’. Few adenomas weighing more than 30 g have been described in the literature. Here we present one such case.Case report: A 52-year-old female presenting with lethargy was found to have a corrected calcium of 3.15 mmol/l with a ...

Introduction: Peptide immunotherapy has been shown to be a simple and effective method of restoring tolerance and reversing disease in animal models of type 1 diabetes. It is highly important to administer the peptide interadermally into an environment in which antigen presenting cells such as dendritic cells are maintained in a tolerogenic state.Objective: Our aim was to determine whether topical pre-treatment of the skin has the potential to enhance to...